IL-31 | American Research Products 19-C053 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

IL-31

catalog :

19-C053

quantity :

10 ug

price :

149.00 USD

product information

Catalog Number :

19-C053

Product Name :

IL-31

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

149.00 USD

Product Description :

Human interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure.It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1.Human IL31 cDNA encodes a 164 amino acid precursor that contains a 23 aa signal peptide and a 141 aa mature protein. Human and mouse IL31 share 24% sequence identity in the mature region.IL 31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL31RA (also GPL and GLMR) and a oncostatin M receptor (OSM Rbeta). The IL31 receptor is constitutively expressed by keratinocytes and upregulated by IFNgamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human IL31 was lyophilized at 1mg/ml in 20mM PBS.