This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
American Research Products
product type :
protein
product name :
IL-1 alpha/IL-1F1
catalog :
19-C041
quantity :
10 ug
price :
149.00 USD
product information
Catalog Number :
19-C041
Product Name :
IL-1 alpha/IL-1F1
Product Type :
Recombinant Protein
Size :
10 ug
List Price :
149.00 USD
Product Description :
IL-1alpha is distinct from the other agonist member of the IL-1 family, IL-1beta. Although IL-1alpha triggers the same IL-1 receptor and although many of the biological effects of IL-1alpha are similar to those of IL-1alpha, in humans IL-1alpha is predominantly an intracellular molecule. In fact, there is evidence that IL-1alpha has both intracellular functions as a precursor molecule due to a nuclear localization sequence. IL-1alpha as an unprocessed precursor is biologically as active as the processed form. IL-1alpha is also found constitutively in epithelial cells, whereas constitutive expression of IL-1beta is rare. In many ways, IL-1alpha appears to be closer to the fibroblast growth factor family than the secreted IL-1beta form. Therapeutic stratiegies for blocking IL-1beta predominate over those for blocking IL-1alpha. Many humans have circulating neutralizing antibodies to IL-1alpha but not IL-1beta.
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Packaging :
Mouse IL-1α was lyophilized after extensive dialysis against PBS.
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
http://www.arp1.com
(800) 832-2611
headquarters: USA