IL-1ra/IL-1F3 | American Research Products 19-C033 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

IL-1ra/IL-1F3

catalog :

19-C033

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C033

Product Name :

IL-1ra/IL-1F3

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1RN is markedly enhanced by IL-1, TNF-alpha, or PDGF.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

IL-1Ra was lyophilized after extensive dialysis against PBS.