LR3-IGF-I(MG) | American Research Products 19-C023 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

LR3-IGF-I(MG)

catalog :

19-C023

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C023

Product Name :

LR3-IGF-I(MG)

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Insulin-like growth factor I (IGF-I),also known as somatomedin C or mechano growth factor, belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 aa is 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-I binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumour progression. IGF-I expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human Long-R3-IGF-I was lyophilized at 1mg/ml in 20mM PBS.