product summary
request information :
company name :
American Research Products
product type :
antibody
product name :
Anti-ERAB
catalog :
17-10324
quantity :
200 ul
price :
179.00 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human
application :
immunohistochemistry
more info or order :
American Research Products product webpage
product information
Catalog Number :
17-10324
Product Name :
Anti-ERAB
Host Species :
Rabbit
Clonality :
polyclonal
Conjugation :
Purified
Product Type :
Rabbit Polyclonal, IgG
Size :
200 ul
List Price :
179.00 USD
Product Description :
Mutations in several genes associated with early onset Alzheimer’s result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer’s disease-affected brain. ERAB may contribute to neuronal dysfunction in Alzheimer’s disease.
Immunogen :
Synthetic peptide derived from internal region of human ERAB protein.
Application Summary :
IHC-P
Storage :
2°-8°C for immediate use. -20°C for long term.
more info or order :
American Research Products product webpage
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
www.arp1.com
(800) 832-2611
headquarters: USA