TRAIL, 114-281 aa, Human, Recombinant, E.coli | American Research Products 12-0113 product information

product summary

company name :

American Research Products

product type :

protein

product name :

TRAIL, 114-281 aa, Human, Recombinant, E.coli

catalog :

12-0113

quantity :

10 ug

price :

129.00 USD

more info or order :

American Research Products product webpage

product information

Catalog Number :

12-0113

Product Name :

TRAIL, 114-281 aa, Human, Recombinant, E.coli

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

129.00 USD

Product Description :

TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumor cell lines upon binding to the death-signalling receptors on the cell membrane. TRAIL binds to one of four receptors that have been identified in humans, including TRAIL-R1/DR4, TRAIL-R2/KILLER/DR5, TRAIL-R3/DcR1/TRID, and TRAIL-R4/DcR2/TRUNDD. Both DR4 and DR5 are pro-apoptotic receptors, which contain a cytoplasmic death domain and mediate apoptosis on binding to TRAIL. By contrast, TRID and TRUNDD do not contain a cytoplasmic death domain and block the function of TRAIL by competing with DR4 and DR5 for binding of TRAIL. Recombinant human TRAIL was expressed in E.coli and purified by using conventional chromatography techniques.

Purity :

> 95% by SDS - PAGE

Packaging :

Liquid in 20mM Tris pH 7.5, 300mM NaCl, 0.1mM DTT, 10% glycerol

Concentration :

1 mg/ml (determined by Bradford assay)

Storage :

Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

General References :

Janssen EM., et al. (2005). Nature. 434(7029):88-93.Deocaris CC., et al. (2007) Ann N Y Acad Sci. 1119:165-75

more info or order :

American Research Products product webpage