Anti-Multidrug Resistance-related Protein (MRP1) | American Research Products 03-57045 product information

product summary

company name :

American Research Products

product type :

antibody

product name :

Anti-Multidrug Resistance-related Protein (MRP1)

catalog :

03-57045

quantity :

100 ul

price :

319.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

American Research Products product webpage

product information

Catalog Number :

03-57045

Product Name :

Anti-Multidrug Resistance-related Protein (MRP1)

Host Species :

Mouse

Clonality :

monoclonal

Conjugation :

Purified

Product Type :

Mouse monoclonal

Size :

100 ul

List Price :

319.00 USD

Clone :

MRPr1

Isotype :

IgG2a

Product Description :

MRP1 (also known as ABCC, GS-X, ABC29) functions as a multispecific organic anion transporter, with (oxidized) glu- tathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. It also transports drugs and other hydrophobic compounds in pres- ence of glutathione

Immunogen :

Bacterial fusion protein containing 168 aa (aa 192-360) in the amino proximal half of MRP1

Specificity :

Mab MRPm1 reacts with the internal epitope of MRP1 (aa 238-247), a 1531 aa protein, overexpressed in various hu- man non-P-glycoprotein MDR tumor cell lines. Does not cross-react with human P-glycoprotein, MDR3 P- glycoprotein or human cMOAT / MRP2 to MRP5

Application Summary :

Immunohistochemistry on frozen- and paraffin sections after microwave treatment (0.01 M Citrate buffer; 3X 3 min at 100°C Immunostaining for cytospin preparations Flow Cytometry (cell permeabilization required) Immunoblotting (western)(180 – 195 kD glycoprotein)

Storage :

2-8°C

General References :

Flens, MJ. et al. (1994) Cancer Res 54: 4557-4563Cole, SPC. et al. (1992) Science 258: 1650-1654Zaman et al. Proc. Natl. Acd. Sci. USA 91: 8822-8826

more info or order :

American Research Products product webpage