Anti-Multidrug Resistance-related Protein (MRP1) | American Research Products 03-57044 product information

product summary

company name :

American Research Products

product type :

antibody

product name :

Anti-Multidrug Resistance-related Protein (MRP1)

catalog :

03-57044

quantity :

100 ul

price :

319.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

American Research Products product webpage

product information

Catalog Number :

03-57044

Product Name :

Anti-Multidrug Resistance-related Protein (MRP1)

Host Species :

Mouse

Clonality :

monoclonal

Conjugation :

Purified

Product Type :

Mouse monoclonal

Size :

100 ul

List Price :

319.00 USD

Clone :

MRPm6

Isotype :

IgG1

Product Description :

MRP1 (also known as ABCC, GS-X, ABC29) functions as a multis- pecific organic anion transporter, with (oxidized) glutathione, cys- teinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of ster- oid hormones and bile salts. It also transports drugs and other hy- drophobic compounds in presence of glutathione

Immunogen :

Bacterial fusion protein containing a 170 aa segment in the carboxy-terminal end and part of the carboxy-proximal nucleotide binding domain of MRP (aa 1294 – 1531)

Specificity :

Mab MRPm6 reacts with an internal epitope of MRP, a 180-195 kD transmembrane transporter protein, overexpressed in various human non-P-glycoprotein MDR tumor cell lines. It does not cross react with the human MDR1 and MDR3 gene products

Application Summary :

Immunohistochemistry on frozen- and paraffin sections after microwave treatment (0.01 M Citrate buffer; 3X 3 min at 100°C Immunostaining for cytospin preparations Flow Cytometry (cell permeabilization required) Immunoblotting (western)(180 – 195 kD glycoprotein)

Storage :

2-8°C

General References :

Flens, MJ. et al. (1994) Cancer Res 54: 4557-4563Cole, SPC. et al. (1992) Science 258: 1650-1654Zaman et al. Proc. Natl. Acd. Sci. USA 91: 8822-8826Flens, MJ et al. (1996) Am J Pathol 148: 1237-1247Nooter et al. (1996) Abb Oncol 7: 75-81

more info or order :

American Research Products product webpage