Anti-VHL | American Research Products 01-2428 product information

product summary

company name :

American Research Products

product type :

antibody

product name :

Anti-VHL

catalog :

01-2428

quantity :

200 ul

price :

179.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

more info or order :

American Research Products product webpage

product information

Catalog Number :

01-2428

Product Name :

Anti-VHL

Host Species :

Mouse

Clonality :

monoclonal

Conjugation :

Purified

Product Type :

Mouse Monoclonal

Size :

200 ul

List Price :

179.00 USD

Clone :

52A11

Product Description :

Von Hippel-Lindau disease (VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich inbeta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF).

Immunogen :

Recombinant human VHL (1-154aa) purified from E. coli

Specificity :

VHL

Concentration :

0.1mg/ml

Storage :

-20°C (aliquot), Avoid repeated freeze and thaw cycles.

General References :

Latif, F., et al (1993) Science. 260(5112),1317-1320 Duan,D.R., et al (1995) Proc.Natl.Acad.Sci. U.S.A. 92(14),6459-6463 Maxwell,P.H., et al (1999) Nature 399(6733), 271-275 Chales E. Stebbins, et al (1999) Science 284, 455-461 Staller, P. et al (2003) Nature 425, 307-311

more info or order :

American Research Products product webpage