Anti-Pin1 | American Research Products 01-2401 product information

product summary

company name :

American Research Products

product type :

antibody

product name :

Anti-Pin1

catalog :

01-2401

quantity :

200 ul

price :

169.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

more info or order :

American Research Products product webpage

product information

Catalog Number :

01-2401

Product Name :

Anti-Pin1

Host Species :

Mouse

Clonality :

monoclonal

Conjugation :

Purified

Product Type :

Mouse Monoclonal

Size :

200 ul

List Price :

169.00 USD

Clone :

3G8

Product Description :

Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLk I, Wee, and Myt1 kinases), several transcription factors likebeta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.

Immunogen :

Recombinant human Pin1 (1-163aa) purified from E. coli

Specificity :

Pin1

Concentration :

0.1mg/ml

Storage :

-20°C (aliquot), Avoid repeated freeze and thaw cycles.

General References :

Wulf GM, et al., (2002) J Biol. Chem. 277(50)47976-47979 Hamdane M, et al., (2002) J Mol Neurosci. 19(3) ; 275-287 Zheng H, et al., (2002) Nature 419(6909) 853-857 Lu kP. et al., (1996) Nature 380(6574) 544-547. Campbell HD, et al., (1997) Genomics 44(2), 157-162

more info or order :

American Research Products product webpage