American Research Products

protein

MAPK11, 1-364aa, Human, His tag, E.coli, Recombinant

01-1755-11

2 ug

169.00 USD

01-1755-11

MAPK11, 1-364aa, Human, His tag, E.coli, Recombinant

Recombinant Protein

2 ug

169.00 USD

MAPK11 (Mitogen-activated protein kinase 11) is a member of the MAP kinase family. This kinase is most closely related to p38 MAP kinases(MAPKs). MAPKs are activated primarily in response to inflammatory cytokines and cellular stress, and inhibitors which target the MAPK14 and MAPK11 have shown potential for the treatment of inflammatory disease. MAPK11 has been shown to interact with HDAC3 and Promyelocytic leukemia protein. This kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Recombinant human MAPK11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

> 90% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 100mM NaCl

1mg/ml (determined by Bradford assay)

Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Beardmore VA, et al. (2005) Mol Cell Biol. 25(23):10454-64.Mahlknecht U, et al. (2004) J Immunol. 173(6):3979-90.