protein

SKP1, 1- 160aa, Human, E.coli, Recombinant

01-1745

20 ug

129.00 USD

SKP1, 1- 160aa, Human, E.coli, Recombinant

Recombinant Protein

20 ug

129.00 USD

S-phase kinase-associated protein 1, also known as SKP1, is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. It is also involved in the control of beta-catenin levels and the activity of beta-catenin dependent TCF transcription factors. Recombinant human SKP1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

> 90% by SDS - PAGE

Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol

1 mg/ml (determined by Bradford assay)

Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Cenciarelli C., et al. (1999) Curr Biol. 9(20): 1177-9.Min KW., et al. (2003) J Biol Chem. 278(18):15905-10.