ZINC9315614 | Alomone Labs Z-145 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ZINC9315614

catalog :

Z-145

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat brain (lanes 1 and 5) mouse brain (lanes 2 and 6) human brain glioblastoma (U-87 MG) (lanes 3 and 7) and mouse brain glioma (C6) cell (lanes 4 and 8) lysates: - 1-4.Anti-NMUR2 (extracellular) Antibody(#ANR-072) (1:200).5-8. Anti-NMUR2 (extracellular) Antibody preincubated with the negative control antigen.

product information

CAT :

Z-145

SKU :

Z-145_10 mg

Product Name :

ZINC9315614

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ZINC9315614 is a selective antagonist of purinergic P2X7 receptors. It binds to the ATP-binding pocket of P2X71. ZINC9315614 inhibits YoPro1 dye uptake and BzATP-induced Ca2+ responses in HEK-human P2X7 cells with IC50 value of 0.8 µM and 3.2 µM, respectively1.P2X receptors are cationic trimeric channel complexes that function as ATP-gated calcium-permeable and are considered to be an attractive therapeutic target. This family contains seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in various cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors can be found in almost all tissues1,2.

Supplier :

Alomone Labs

Target :

P2X7 receptors

Long Description :

ZINC9315614 (#Z-145) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of P2X7 Receptors

MW :

328.74

Synonyms :

ZINC09315614, Z26888283, N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide

Source :

Synthetic

Molecular formula :

C13H10ClFN2O3S.

Effective Concentration :

0.1-10 µM.

Activity :

ZINC9315614 is a novel antagonist of the purinergic P2X7 receptors, shown to inhibit YoPro1 uptake and BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 of 0.8 µM and 3.2 µM, respectively1.

Reconstitution and Solubility :

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CID :

17392877

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[(2-chloro-6-fluorophenyl)methyl]-N-methyl-5-nitrothiophene-2-carboxamide.

more info or order :

Alomone Labs product webpage