ZINC58368839 | Alomone Labs Z-135 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ZINC58368839

catalog :

Z-135

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Bin Dayel A, Evans R, Schmid R. Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket. Mol Pharmacol. 2019;96:355-363 pubmed publisher

image

image 1 :

Expression of Kir6.2 in mouse hippocampus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sectionsusing Guinea pigAnti-Kir6.2 Antibody (#AGP-067) (1:300) followed by goat-anti-guinea pig-Cy3 antibody (red staining).Kir6.2staining appears in the hilus region in neuronal outlines (arrows). Nuclei are stained with DAPI (blue).

product information

CAT :

Z-135

SKU :

Z-135_10 mg

Product Name :

ZINC58368839

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ZINC58368839 inhibits P2X7 receptors by binding to the ATP-binding pocket of the receptor and demonstrates strong specificity towards human P2X7R over human P2X4R and rat P2X3R1. It inhibits BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 value of 4.8 µM1.P2X receptors are cationic trimeric channel complexes that function as ATP-gated Ca2+-permeable channels. They are considered to be an attractive therapeutic target. This family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are ubiquitously expressed, and particularly in cells of haematopoietic origin1,2.

Supplier :

Alomone Labs

Target :

P2X7 channels

Long Description :

ZINC58368839 (#Z-135) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of P2X7 Receptors

MW :

329.39

Synonyms :

N-cycloheptyl-N-methyl-2-(5-nitro-1H-indol-1-yl)acetamide, T6869826, Z905437510

Source :

Synthetic

Molecular formula :

C18H23N3O3.

Effective Concentration :

5-50 µM.

Activity :

ZINC58368839 is a novel antagonist of purinergic P2X7 receptors, shown to inhibit BzATP-induced Ca2+ responses in HEK-hP2X7 cells with IC50 of 4.8 µM1.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CID :

51127177

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-cycloheptyl-N-methyl-2-(5-nitroindol-1-yl)acetamide.

more info or order :

Alomone Labs product webpage