Zacopride hydrochloride | Alomone Labs Z-110 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Zacopride hydrochloride

catalog :

Z-110

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone LabsZacopride hydrochlorideblocks 5-HT3A receptors expressed in HEK 293T cells. - Currents were elicited by 10 M 5-HT delivered every 3 minutes.Zacopride hydrochloride(#Z-110) was applied 30 seconds before stimulation at 1 10 and 100 nM as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.

image 2 :

product information

CAT :

Z-110

SKU :

Z-110_10 mg

Product Name :

Zacopride hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Zacopride hydrochloride is a derivative of benzamide, described as a potent 5-HT3 receptor antagonist with 5-HT4 receptor agonistic properties. Zacopride is a recemic compound. Studies showed that the S(-) form has a higher binding affinity for central and peripheral 5-HT3 receptor compared to R(+) zacopride1. Ki values for 5-HT3 and 5-HT4 receptors are 0.38 nM and 373 nM respectively3.There is some evidence from animal behavioral experiments that 5-HT3 receptor antagonists may be useful as anxiolytics, antipsychotics, cognition-enhancers and anti-addictive agents. It has been reported from these models that the S(-) enantiomer is potent in animal models of psychosis whereas the R(+) enantiomer is more potent in anxiety models1.Zacopride has been shown to be an effective anti-emetic agent against the emesis induced by cytotoxins and radiation in dogs, cats, non-human primates and ferrets2.

Supplier :

Alomone Labs

Target :

5-HT3, 5-HT4 receptors

Long Description :

Zacopride hydrochloride (#Z-110) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of 5-HT3 Receptors and an Agonist of 5-HT4 Receptors

MW :

346.25

Source :

Synthetic

Molecular formula :

C15H21Cl2N3O2.

Effective Concentration :

0.3-300 nM.

Activity :

Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM)1.

Reconstitution and Solubility :

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

99617-34-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide hydrochloride.

more info or order :

Alomone Labs product webpage