YM 90K hydrochloride | Alomone Labs Y-105 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

YM 90K hydrochloride

catalog :

Y-105

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: - 12.Anti-HCN3 (extracellular)Antibody (#APC-083) (1:200).34. Anti-HCN3 (extracellular) Antibody preincubated with the negative control antigen.Note:Samples were heated to 37C prior to loading on gel.

product information

CAT :

Y-105

SKU :

Y-105_10 mg

Product Name :

YM 90K hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

YM 90K is a selective and potent AMPA receptor antagonist. YM 90K inhibits the binding of [3H] AMPA with a Ki value of 84 nM1.YM 90K has been reported to have neuroprotective effects in focal and global cerebral ischaemia models. However, high or moderate doses of YM 90K induce behavioral changes, including sedation, muscular hypotonia and ataxia. In addition, the effects of YM 90K are short-lived. In this context, YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.YM 90K could be clinically useful, since a low dose exhibits significant, although weak effects against kindling without detectable behavioral adverse effects2.

Supplier :

Alomone Labs

Target :

AMPA receptors

Long Description :

YM 90K hydrochloride (#Y-105) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of AMPA Receptors

MW :

309.9

Source :

Synthetic

Molecular formula :

C11H8ClN5O4.

Effective Concentration :

50 nM - 50 µM.

Activity :

YM 90K hydrochloride is a selective AMPA receptor antagonist; Ki of 84 nM1.

Reconstitution and Solubility :

10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).

Solubility :

10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

154164-30-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride.

more info or order :

Alomone Labs product webpage