chemical

Azasetron hydrochloride

Y-100

Y-100_10 mg

Azasetron hydrochloride

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Azasetron hydrochloride (Y-25130 hydrochloride) is a potent 5-HT3 receptor antagonist. It selectively and competitively binds 5-HT3 receptors thereby blocking the serotonin binding site. Azasetron is classified as a derivative of benzamide. It has a different chemical structure from other 5-HT3 receptor blockers. The significant difference is found in the pharmacokinetic profiles resulting in a longer duration of action and a higher affinity for the 5-HT3 receptor1,2. Azasetron has an IC50 value ~4.9x10-10 M4 and half life of 5.4 hours3.The 5-HT3 receptor subtype is a member of the Cys-loop ligand-gated cation channels which are expressed throughout the central and peripheral nervous systems and mediate a variety of physiological functions5.Azasetron is mostly administered orally and by I.V (60-70%) and excreted in the urine in an unmetabolized form. Orally-administered azasetron is shown to be absorbed and secreted by the saturable transport mechanism in the small intestine, resulting in good bioavailability (approximately 90%)2.5-HT3 receptor antagonists have been established in a number of clinical trials as effective agents in the management and prevention of nausea and vomiting caused by cancer chemotherapy as well as postoperative nausea and emesis after anesthesia and surgery1,3.

Alomone Labs

5-HT3 receptors

Azasetron hydrochloride (#Y-100) is a highly pure, synthetic, and biologically active compound.

A Potent Antagonist of Serotonin-Gated Channels

386.3

Y-25130 hydrochloride

Synthetic

C17H21Cl2N3O3.

0.1-100 nM.

Azasetron hydrochloride is a potent 5-HT3 channel blocker with a Ki ~2.9 nM1.

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

123040-16-4

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;hydrochloride.