XEN907 | Alomone Labs X-105 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

XEN907

catalog :

X-105

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Fung Leung W, EDWARDS W, Liu Y, Ngo K, Angsana J, Castro G, et al. T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers. PLoS ONE. 2017;12:e0170102 pubmed publisher

image

image 1 :

Alomone Labs (S)-Duloxetine hydrochloride blocks KV4. 3 channels expressed inXenopusoocytes. - A. Time course of KV4.3 current amplitude and inhibition by 100 and 300 M(S)-Duloxetine hydrochloride(#D-170). Currents were elicited by application of voltage step from a holding potential of -80 mV to +20 mV (150 msec) every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 and 300 M (S)-Duloxetine hydrochloride as indicated.

product information

CAT :

X-105

SKU :

X-105_10 mg

Product Name :

XEN907

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Voltage-gated sodium (NaV) channels contribute to physiological and pathophysiological electrical signaling in nerve and muscle cells. NaV1.7 is highly expressed on the axons of somatic afferent neurons and is thought to play an important role in the signaling of inflammatory pain.XEN907 is a synthetic blocker of NaV1.7 channels. It has an effective concentration of 1 nM - 10 μM and an IC50 of 5 nM for NaV1.7 in its inactive state. XEN907 is highly specific for NaV1.7 and at a concentration of 10 μM was not found to have significant activity against some 63 receptors and transporters examined1. XEN907 is not toxic and has favorable hepatocyte metabolic stability in humans and dogs, although inhibition of CYP3A4 was observed in a recombinant human enzyme assay. XEN907 has 97% plasma protein binding property in rat. XEN907 exhibits modest bioavailability of 13% and a T0.5 of 2.6±0.1 hours. XEN907 is extensively distributed when administered intravenously and has a clearing rate of 9.4±1.7 (L/h/kg)1.

Supplier :

Alomone Labs

Target :

NaV1.7 channels

Long Description :

XEN907 (#X-105) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Specific Blocker of NaV1.7 Channels

MW :

351.1

Source :

Synthetic

Molecular formula :

C21H21N4O.

Effective Concentration :

1 nM - 10 µM.

Activity :

XEN907 is a NaV1.7 channel blocker with an IC50 value of 5 nM for the channel in its inactivated state1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99% (HPLC)

CAS No :

912656-34-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1'-pentylspiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one.

more info or order :

Alomone Labs product webpage