XE991 dihydrochloride | Alomone Labs X-101 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

XE991 dihydrochloride

catalog :

X-101

more info or order :

Alomone Labs product webpage

citations: 3

Reference
Inagaki A, Hayashi M, Andharia N, Matsuda H. Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch. 2019;471:313-327 pubmed publisher
Li L, Sun H, Ding J, Niu C, Su M, Zhang L, et al. Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour. Br J Pharmacol. 2017;174:4277-4294 pubmed publisher
Lee K, Royston S, Vest M, Ley D, Lee S, Bolton E, et al. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. Mol Brain. 2015;8:4 pubmed publisher

image

image 1 :

Alomone Labs XE991 dihydrochloride blocks KCNQ2/KCNQ3 channels heterologously expressed inXenopusoocytes. - A. Time course of KCNQ2/KCNQ3 maximal current amplitude elicited by 700 ms voltage step from holding potential of -100 mV to -30 mV delivered every 10 seconds. Application of 100 MXE991 dihydrochloride(#X-101) inhibits the KCNQ2/KCNQ3 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 100M XE991 dihydrocloride as indicated.

product information

CAT :

X-101

SKU :

X-101_10 mg

Product Name :

XE991 dihydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Voltage-gated K+ channels of the KCNQ family (KV7) are widely expressed in nerves and smooth muscles where their general role is to hyperpolarise the cell membrane and thereby dampen excitability1.XE991 is a potent and selective blocker of KCNQ voltage-gated K+ channels. It blocks KV7.2 + KV7.3 (KCNQ2 + KCNQ3)/M-currents (IC50 = 0.6 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM)1. Suppression of the M-current causes an increase in intrinsic excitability2. XE991 enhances acetylcholine release from rat brain slices (EC50 = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer's disease therapeutics2. It was demonstrated that XE991 enhances learning and memory in healthy mice3.

Supplier :

Alomone Labs

Target :

KCNQ K+ channels

Long Description :

XE991 dihydrochloride (#X-101) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of KCNQ Channels

MW :

449.37

Source :

Synthetic

Molecular formula :

C26H22Cl2N2O.

Effective Concentration :

0.1-300 µM.

Activity :

XE991 blocks KCNQ channels with IC50 of 0.5-10 µM1.

Reconstitution and Solubility :

Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.

Solubility :

Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

122955-13-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride.

more info or order :

Alomone Labs product webpage