chemical

WS 12

W-105

W-105_10 mg

WS 12

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

The carboxamide WS 12 is a synthetic selective TRPM8 channel agonist1.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP proteins and is activated by temperatures or by cooling compounds such as icilin, menthol and eucalyptol. The TRPM8 gene is expressed and is up-regulated in prostate cancer and other malignancies. It is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons1-3.

Alomone Labs

TRPM8 channel

WS 12 (#W-105) is a highly pure, synthetic, and biologically active compound.

An Activator of TRPM8 Channel

289.41

(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

Synthetic

C18H27NO2.

1 nM - 10 µM.

WS 12 is a TRPM8 channel activator (EC50 = 193 nM)1.

Up to 75 mM in Ethanol. Centrifuge all products before use (10000 x g 5 min).

Up to 75 mM in Ethanol. Centrifuge all products before use (10000 x g 5 min).

Up to three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

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Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide.