WS 3 | Alomone Labs W-100 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

WS 3

catalog :

W-100

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs WS 3 activates TRPM8 channel expressed in HEK-293 cells. - Dose response curve for the activation of human TRPM8 by increseaingWS 3(#W-100) concentrations. EC50is estimated at 0.43 M. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+were detected via changes in 485 nm/525 nm fluorescence following agonist application.

product information

CAT :

W-100

SKU :

W-100_1 g

Product Name :

WS 3

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

WS 3 is a synthetic, selective TRPM8 channel agonist with an EC50 value of 3.7 μM1,3.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP proteins and is activated by temperatures or by cooling compounds such as icilin, menthol and eucalyptol. The TRPM8 gene is expressed and is up-regulated in prostate cancer and other malignancies. It is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons1-3.

Supplier :

Alomone Labs

Target :

TRPM8 channel

Long Description :

WS 3 (#W-100) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Activator of TRPM8 Channel

MW :

211.34

Synonyms :

N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide, Ethyl menthane carboxamide, N-Ethyl-p-menthane-3-carboxamide, N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide

Source :

Synthetic

Molecular formula :

C13H25NO.

Effective Concentration :

0.1-10 µM.

Activity :

WS 3 is a TRPM8 channel activator (EC50 = 3.7 μM)1.

Reconstitution and Solubility :

Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

39711-79-0

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide.

more info or order :

Alomone Labs product webpage