Verruculogen | Alomone Labs V-500 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Verruculogen

catalog :

V-500

more info or order :

Alomone Labs product webpage

citations: 6

Reference
Morelli A, Sumpter T, Rojas Canales D, Bandyopadhyay M, Chen Z, Tkacheva O, et al. Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells. Cell Rep. 2020;30:3448-3465.e8 pubmed publisher
So E, Gao Z, Ko S, Wu S. Characterization of Effectiveness in Concerted Ih Inhibition and IK(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid. Int J Mol Sci. 2020;21: pubmed publisher
Liu Y, Fang Y, Su C, Hwang S, Liu P, Wu S. The biochemical and electrophysiological profiles of amniotic fluid-derived stem cells following Wnt signaling modulation cardiac differentiation. Cell Death Discov. 2019;5:59 pubmed publisher
Hsu H, Tseng Y, Lo Y, Wu S. Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with Î±-hSlo subunit. BMC Neurosci. 2014;15:135 pubmed publisher
Ishii H, Nakajo K, Yanagawa Y, Kubo Y. Identification and characterization of Cs(+) -permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. Eur J Neurosci. 2010;32:736-48 pubmed publisher
Zhou Y, Tang Q, Xia X, Lingle C. Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. J Gen Physiol. 2010;135:481-94 pubmed publisher

image

image 1 :

Verruculogen inhibits KCa1.1 channels inXenopusoocytes. - Time course of KCa1.1 channel current amplitude upon application of several mycotoxins includingVerruculogen(#V-500). Current amplitude was reduced by 100 nMPaxilline(#P-450) (a)Penitrem A(#P-650) (b) and Verruculogen (c). The horizontal bars represent the period of toxin perfusion.

product information

CAT :

V-500

SKU :

V-500_0.51 mg

Product Name :

Verruculogen

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Verruculogen is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A (#P-650) and Paxilline (#P-450).2Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Verruculogen had similar effects to Iberiotoxin (#STI-400) in inhibiting the early Ca2+ dependent K+ current in CA1 pyramidal cells.3

Supplier :

Alomone Labs

Target :

KCa1.1 K+ channels

Long Description :

Verruculogen (#V-500) is a highly pure, natural, and biologically active compound.

Short Description :

A Blocker of KCa1.1 (BK) Channels

MW :

511.23

Source :

Natural

Molecular formula :

C27H33N3O7.

Effective Concentration :

10-100 nM.

Activity :

Verruculogen is a selective blocker of KCa1.1 (BK) channel. It belongs to a set of tremorgenic indole alkaloids1.

Reconstitution and Solubility :

DMSO, methanol or acetone.

Solubility :

DMSO, methanol or acetone.

Storage of solutions :

Up to two weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

12771-72-1

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5H,12H-3,4-Dioxa-5a,11a,15atriazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione,1,10,10a,14,14a,15b-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propenyl)-,(5R,10S,10aR,14aS,15bS).

more info or order :

Alomone Labs product webpage