VU590 dihydrochloride | Alomone Labs V-130 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

VU590 dihydrochloride

catalog :

V-130

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Andrade A, Sandoval A, González Ramírez R, Lipscombe D, Campbell K, Felix R. The alpha(2)delta subunit augments functional expression and modifies the pharmacology of Ca(V)1.3 L-type channels. Cell Calcium. 2009;46:282-92 pubmed publisher

image

image 1 :

product information

CAT :

V-130

SKU :

V-130_10 mg

Product Name :

VU590 dihydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

VU590 dihydrochloride is a synthetic blocker of Kir1.1 channel with an IC50 of 294nM for Kir1.1 channel. VU590 also inhibits Kir7.1 channels at micromolar concentrations whilst having no effect on Kir2.1 or Kir4.1 channels. At a voltage of -120mV VU590 inhibits Kir1.1 currents by 95.3±0.5%. Inhibition of the Kir1.1 channel is dose dependent. 10 µM of VU590 cause a slow rate inhibition of Kir1.1 with a time constant of 40.0±0.5 s suggesting that VU590 first has to cross the plasma membrane in order to reach its binding site. Kir1.1 block by VU590 is relieved by hyperpolarizing pulses and increased extracellular K+ concentrations. This is hypothesized to be achieved by increased blocker dissociation into the cytoplasmic compartment when exposed to these conditions. The binding site of VU590 within the Kir1.1 channel is yet to be determined1.

Supplier :

Alomone Labs

Target :

Kir1.1, Kir7.1 channels

Long Description :

VU590 dihydrochloride (#V-130) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of Kir1.1 and Kir7.1 K+ Channels

MW :

561.46

Synonyms :

ML111, AOB1540

Source :

Synthetic

Molecular formula :

C24H34Cl2N4O7.

Effective Concentration :

0.1-25 µM.

Activity :

VU590 inhibits ROMK1 channels in a dose-dependent manner with an IC50 of 294 nM. Inhibits Kir7.1 at micromolar concentrations, whilst having no effect on Kir2.1 or Kir4.11.

Reconstitution and Solubility :

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98% (HPLC)

CAS No :

313505-85-0

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride.

more info or order :

Alomone Labs product webpage