chemical

VU591

V-125

V-125_10 mg

VU591

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

VU591 is a potent and selective blocker of renal outer medullary potassium channel, ROMK (Kir1.1). Kir1.1 channel is a putative drug target for a novel class of loop diuretic drugs that hold the ability to lower pressure and blood volume without causing hypokalemia. VU591 seems to block the intracellular pore of the channel and does so with an IC50 of 300 nM.ROMK channels are expressed in the thick ascending limb of Henle's loop, connecting tubule, and collecting duct segments of the nephron. They mediate K+ secretion into the urinary filtrate. ROMK provides K+ ions in the thick ascending limb that are necessary for NaCl reabsorption by the Na+-K+-2Cl− cotransporter and loop diuretic target. In the connecting tubule and collecting duct, ROMK constitutes a key pathway for K+ secretion.Evidence shows that ROMK antagonists could serve as potent diuretic drugs by inhibiting Na+ reabsorption in the thick ascending limb of Henle's loop and minimizing urinary K+ ions loss in the collecting duct. Thus, administration of VU591, a direct diuretic, can avoid hypokalemia, a side effect caused from treatment of conventional loop and thiazide diuretics in cases of hypertension and congestive heart failure.

Alomone Labs

Kir1.1 channel

VU591 (#V-125) is a highly pure, synthetic, and biologically active compound.

A Blocker of Kir1.1 Channel

368.3

Synthetic

C16H12N6O5.

0.1-50 µM.

VU591 is a Kir1.1 channel blocker1.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

≥99%

1222810-74-3

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

6-nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole.