VUF 10166 | Alomone Labs V-115 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

VUF 10166

catalog :

V-115

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone LabsVUF 10166blocks 5-HT3A receptors expressed in HEK 293T cells. - Currents were elicited by 10 M 5-HT delivered every 3 minutes.VUF 10166(#V-115) was applied 30 seconds before stimulation at 1 10 and 100 nM as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.

product information

CAT :

V-115

SKU :

V-115_10 mg

Product Name :

VUF 10166

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

VUF 10166 is a potent and selective antagonist of 5-HT3A and B receptors. It binds specifically and with high affinity to 5-HT3A (IC50 ~ 0.04 nM) and blocks the serotonin binding site. There's evidence of lower affinity to 5-HT3A/B receptors due to the influence of an additional allosteric binding site in the heteromer2.VUF 10166 is able to bind to an orthosteric binding site of HT3A and 5-HT3A/B receptors - A+A− and an A+B− interface. binding to the A+B− interface in the 5-HT3A/B receptor may decrease the affinity of ligands binding to the A+A− site by allosterically increasing the rate of ligand dissociation from the adjacent orthosteric site1,3.The 5-HT3 receptor subtype is a member of the Cys-loop ligand-gated cation channels which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions4.Competitive antagonists of 5-HT3 receptors are used to treat symptoms of emesis arising from chemotherapy treatment and postoperative emesis after anesthesia and surgery. There is also a limited use of antagonists for treating irritable bowel syndrome2.

Supplier :

Alomone Labs

Target :

5-Hydroxytryptamine Receptor 3A and 3B

Long Description :

VUF 10166 (#V-115) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of 5-Hydroxytryptamine Receptor 3A and 3B, and an Antagonist of H4 Histamine Receptor

MW :

262.74

Source :

Synthetic

Molecular formula :

C13H15Cl2N4.

Effective Concentration :

0.05 nM - 100 nM.

Activity :

VUF 10166 is a potent and selective 5-HT3A and B receptor antagonist1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

155584-74-0

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline.

more info or order :

Alomone Labs product webpage