Veratridine | Alomone Labs V-110 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Veratridine

catalog :

V-110

more info or order :

Alomone Labs product webpage

citations: 4

Reference
Klima S, Brüll M, Spreng A, Suciu I, Falt T, Schwamborn J, et al. A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling. Arch Toxicol. 2021;95:1703-1722 pubmed publisher
Yang M, James A, Suman R, Kasprowicz R, Nelson M, O Toole P, et al. Voltage-dependent activation of Rac1 by Nav 1.5 channels promotes cell migration. J Cell Physiol. 2020;235:3950-3972 pubmed publisher
Tay B, Stewart T, Davis F, Deuis J, Vetter I. Development of a high-throughput fluorescent no-wash sodium influx assay. PLoS ONE. 2019;14:e0213751 pubmed publisher
Deuis J, Wingerd J, Winter Z, Durek T, Dekan Z, Sousa S, et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016;8: pubmed publisher

image

image 1 :

Alomone Labs Veratridine modulates NaV1.4 Na+currents inXenopusoocytes. - A. Superimposed example current traces of NaV1.4 channels before (black) and during application of 100 ?MVeratridine(#V-110) (green). Note that the current is inhibited during the peak but is enhanced at its end and especially once the membrane potential is back to rest (tail). B. Time course of NaV1.4 channel activity (measured at the tail current) before and during applications of 100 ?M Veratridine (green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV.

product information

CAT :

V-110

SKU :

V-110_10 mg

Product Name :

Veratridine

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Veratridine is an alkaloid extracted from the Veratrum officinale plant. It is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability of NaV1.4 channels expressed in a mammalian cell line3. Veratridine affects differentially the TTX-sensitive and TTX-resistant components of NaV currents in rat DRG neurons. Although veratridine inhibits both components at the peak current, it is much more effective in increasing the persistent component (channel opening) of the TTX-sensitive current4. Veratridine is widely used in different excitable preparations to induce NaV channel dependent transmitter release (see for example reference #5).

Supplier :

Alomone Labs

Target :

Various NaV Na+ channels

Long Description :

Veratridine (#V-110) is a highly pure, natural, and biologically active compound.

Short Description :

An Enhancer of NaV Channel Activity and an Inducer of Transmitter Release

MW :

673.8

Source :

Natural

Molecular formula :

C36H51NO11.

Effective Concentration :

1-200 μM.

Activity :

Veratridine is an alkaloid which is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability3.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

71-62-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol.

more info or order :

Alomone Labs product webpage