UBP 282 | Alomone Labs U-110 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

UBP 282

catalog :

U-110

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide (C)GYKKNWRKAPLSELE corresponding to amino acid residues 776-790 of rat NKCC2 (AccessionP55016). 6thextracellular loop.

product information

CAT :

U-110

SKU :

U-110_10 mg

Product Name :

UBP 282

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

UBP 282 (3-CBW) is a synthetic willardiine analogue that acts as an antagonist of AMPA and Kainate glutamate receptors. The compound fully inhibits AMPA-evoked responses in neonatal motoneurons at 200 µM and reduces the AMPA-mediated fast component of dorsal root-evoked ventral root potential with IC50 value of 10.3 µM1,2.The ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. This function is essential for synaptic plasticity and learning and memory3,4.Kainate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability, and synaptogenesis5.

Supplier :

Alomone Labs

Target :

AMPA, Kainate receptors

Long Description :

UBP 282 (#U-110) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of AMPA and Kainate Receptors

MW :

333.29

Synonyms :

3-CBW

Source :

Synthetic

Molecular formula :

C15H15N3O6.

Effective Concentration :

10-200 µM.

Activity :

UBP 282 is an antagonist of AMPA and kainate glutamate receptors. It reduces the AMPA-mediated fast component of dorsal root-evoked ventral root potential with IC50 of 10.3 µM, and fully inhibits AMPA-evoked responses in neonatal motoneurons at 200 µM. It differentially antagonizes kainate-induced responses in dorsal root C-fibres with pA2 of 4.96, but not in spinal neonatal rat motoneurons at 200 µM1,2.

Reconstitution and Solubility :

Soluble up to 100 mM in 1 eq. NaOH. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble up to 100 mM in 1 eq. NaOH. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

544697-47-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

4-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid.

more info or order :

Alomone Labs product webpage