Triacsin C | Alomone Labs T-750 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Triacsin C

catalog :

T-750

more info or order :

Alomone Labs product webpage

citations: 2

Reference
Narita T, Naganuma T, Sase Y, Kihara A. Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases. Sci Rep. 2016;6:25469 pubmed publisher
Gandotra S, Lim K, Girousse A, Saudek V, O Rahilly S, Savage D. Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5). J Biol Chem. 2011;286:34998-5006 pubmed publisher

image

image 1 :

Alomone Labs Triacsin C inhibits the proliferation of 3T3-L1 cells. - Cells were treated with different concentrations ofTriacsin C(#T-750) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit normalized to the control (100%) and plotted against the drug concentration.

product information

CAT :

T-750

SKU :

T-750_0.2 mg

Product Name :

Triacsin C

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Triacsin C is a fungal metabolite from Streptomyces aureofaciens1 which almost completely inhibits de novo synthesis of triacylglycerol and phospholipid.2,3 This compound specifically inhibits the activity of long chain acyl-CoA synthetase 1 and 4 (IC50~8µM) but has no effect on the activity of acyl-CoA synthetase 5, in intact cells and in cell lysates. Inhibition of these enzymes causes a decrease in the cellular levels of acyl-CoA precursors for lipid synthesis activity, cell proliferation and lipid transformation.4 Kinetic analysis indicates that inhibition of acyl-CoA synthetase by Triacsin C is not competitive with respect to the two substrates of acyl-CoA synthetase (ATP and coenzyme A), but is competitive with respect to long-chain fatty acids. The N-hydroxytriazene moiety of Triacsin C has been suggested to be essential for the inhibitory activity against acyl-CoA synthetase.2-4Triacsin C arrests the metabolism of arachidonic acid by inhibition of arachidonoyl-CoA synthetase thus interfering in the production of prostaglandins and in the regulation of blood pressure.5

Supplier :

Alomone Labs

Long Description :

Triacsin C (#T-750) is a highly pure, natural, and biologically active compound.

Short Description :

An Acyl CoA Synthase Inhibitor

MW :

207.3

Source :

Natural

Molecular formula :

C11H17N3O.

Effective Concentration :

>10 nM.

Activity :

Triacsin C nearly completely inhibits de novo synthesis of triacylglycerol and phospholipids1,2.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to two weeks at 4°C or six months at -20°C.Protect from light.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>94%

CAS No :

76896-80-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[(E)-[(2E,4E,7E)-undeca-2,4,7- trienylidene]amino]nitrous amide.

more info or order :

Alomone Labs product webpage