Tyrphostin AG 490 | Alomone Labs T-700 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Tyrphostin AG 490

catalog :

T-700

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Tyrphostin AG 490 inhibits the proliferation of Jurkat cells. - Cells were treated with different concentrations ofTyrphostin AG 490(#T-700) for 4 days. Cell survival was measured after 4 days using the XTT method calculated as a relative percentage of the control without Tyrphostin AG 490 and plotted against drug concentrations.

image 2 :

product information

CAT :

T-700

SKU :

T-700_5 mg

Product Name :

Tyrphostin AG 490

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Tyrphostin AG-490 (AG-490) is synthetic tyrphostin derived from benzylidine malononitrile.1 At relatively low concentrations, AG-490 was found to be a highly efficient tyrosine kinase inhibitor for hyperactive forms of Jun kinase 2, 3 and 5 (Jak 2,3, and 5).While many kinase inhibitors are often promiscuous in the enzymes they target, AG-490 is unique in that it does not inhibit other lymphocytic tyrosine kinases such as Lck, Lyn, Btk, Syk, Src, Jak1, Zap70 or Tyk2. 2-6 AG-490 has also been shown to inhibit cytokine-induced activation of JAK2 in eosinophils stimulated with granulocyte-macrophage and in vascular smooth muscle cells and cardiac myocytes activated by angiotensin II. 7-9Some studies have demonstrated that AG-490 efficiently blocks STAT3 activation in mycosis fungoides-derived T cell lymphoma cells and induces apoptosis in myeloma cells.10-11

Supplier :

Alomone Labs

Target :

JAK

Long Description :

Tyrphostin AG 490 (#T-700) is a highly pure, synthetic, and biologically active compound.

Short Description :

A JAK Inhibitor

MW :

294.31

Source :

Synthetic

Molecular formula :

C17H14N2O3.

Effective Concentration :

10 nM - 1 µM.

Activity :

Tyrphostin AG 490 is a potent inhibitor of JAK2 and JAK3. In addition, Tyrphostin AG 490 inhibits the JAK3/STAT, JAK3/AP-1, and JAK3/MAPK pathways and their cellular consequences1.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to two weeks at 4°C or six months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

134036-52-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide.

more info or order :

Alomone Labs product webpage