Thapsigargin Epoxide | Alomone Labs T-670 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Thapsigargin Epoxide

catalog :

T-670

more info or order :

Alomone Labs product webpage

image

image 1 :

product information

CAT :

T-670

SKU :

T-670_50 mcg

Product Name :

Thapsigargin Epoxide

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Thapsigargin, derived from the plant genus Thapsia1,2, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores3 by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation4. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines5. It has also been shown to cause histamine secretion from rat mast cells6 and to stimulate arachidonic acid metabolism in macrophages7. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in the skin8.Thapsigargin Epoxide is a non-active analogue of Thapsigargin and can be used as a negative control for Thapsigargin activity9,10.

Supplier :

Alomone Labs

Target :

SERCA

Long Description :

Thapsigargin Epoxide (#T-670) is a highly pure, natural, and biologically active compound.

Short Description :

A Nonactive Analogue of Thapsigargin

MW :

632.75

Source :

Natural

Molecular formula :

C34H48O11.

Effective Concentration :

100 nM.

Activity :

Thapsigargin is an extremely tight-binding inhibitor of intracellular Ca2+ pumps, but initially described as a tumor promoting agent which induces rapid Ca2+ release from intracellular stores1. Thapsigargin epoxide is a non-active analogue of Thapsigargin.

Reconstitution and Solubility :

DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to one week at 4°C or six months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

67526-95-8

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Chemical Name :

(3S,3aR,4S,6S,6aR,7S,8S,9bS)-3,3a-dihydroxy-3,6,9-trimethyl-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4,6,7,8-tetrayl 6-acetate 4-butanoate 8-[(2Z)-2-methylbut-2-enoate] 7-octanoate.

more info or order :

Alomone Labs product webpage