4,9-Anhydrotetrodotoxin | Alomone Labs T-560 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

4,9-Anhydrotetrodotoxin

catalog :

T-560

more info or order :

Alomone Labs product webpage

citations: 3

Reference
McGrady N, Risner M, Vest V, Calkins D. TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma. Front Physiol. 2020;11:249 pubmed publisher
Meredith F, Rennie K. Regional and Developmental Differences in Na+ Currents in Vestibular Primary Afferent Neurons. Front Cell Neurosci. 2018;12:423 pubmed publisher
Browne L, Smith K, Jagger D. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. Eneuro. 2017;4: pubmed publisher

product information

CAT :

T-560

SKU :

T-560_5 mcg

Product Name :

4,9-Anhydrotetrodotoxin

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

4,9-Anhydrotetrodotoxin, also called 4,9-anhydro-TTX, is a derivative of tetrodotoxin, a potent neurotoxin found in a number of marine creatures including the pufferfish. 4,9-Anhydro-TTX acts as a potent and selective NaV1.6 channel blocker with an IC50 value of 7.8 nM1.4,9-Anhydrotetrodotoxin was found to block the activity of NaV1.6 channels with an efficacy of 40-160 times higher than other tetrodotoxin sensitive NaV1.x channel isoforms. The compound successfully prevents the influx of Na+ ions by blocking the pore of the NaV channel from the extracellular side of the plasma membrane2.4,9-Anhydrotetrodotoxin has become a useful pharmacological tool for the investigation and identification of the biophysical properties of NaV1.6 channels2.Voltage-gated sodium (NaV) channels are responsible for initiating action potentials in electrically excitable cells. NaV channels play an important role in human pain signaling pathways and are an important therapeutic target for the treatment of chronic pain. Mutations in NaV channels are also associated with a range of complex pathologic conditions such as epilepsy, myotonic conditions and cardiac arrhythmias3,4.

Supplier :

Alomone Labs

Target :

NaV1.6 channel

Long Description :

4,9-Anhydrotetrodotoxin (#T-560) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Blocker of NaV1.6 Channel

MW :

301.25

Synonyms :

4,9-anhydro-TTX, Anhydroepitetrodotoxin

Source :

Synthetic

Molecular formula :

C11H15N3O7.

Effective Concentration :

0.1-100 nM.

Activity :

4,9-Anhydrotetrodotoxin, a derivative of tetrodotoxin, is a potent blocker of the NaV1.6 channel (IC50 = 7.8 nM), selective over other TTX-sensitive sodium channels1.

Reconstitution and Solubility :

Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.

Solubility :

Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.

Storage of solutions :

Unstable. Avoid storing in aqueous solution. Prepare fresh daily and use immediately. Toxic.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98% (HPLC)

CAS No :

13072-89-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)- 6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol.

more info or order :

Alomone Labs product webpage