tBuBHQ | Alomone Labs T-220 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

tBuBHQ

catalog :

T-220

more info or order :

Alomone Labs product webpage

citations: 3

Reference
Kang F, Zhou M, Huang X, Fan J, Wei L, Boulanger J, et al. E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca2+ Store Replenishment. Sci Rep. 2019;9:3975 pubmed publisher
Molla B, Muñoz Lasso D, Riveiro F, Bolinches Amorós A, Pallardo F, Fernandez Vilata A, et al. Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice. Front Mol Neurosci. 2017;10:264 pubmed publisher
Bolinches Amorós A, Molla B, Pla Martín D, Palau F, Gonzalez Cabo P. Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism. Front Cell Neurosci. 2014;8:124 pubmed publisher

image

image 1 :

product information

CAT :

T-220

SKU :

T-220_1 g

Product Name :

tBuBHQ

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.

Supplier :

Alomone Labs

Target :

SERCA

Long Description :

tBuBHQ (#T-220) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase

MW :

222.33

Synonyms :

DBHQ

Source :

Synthetic

Molecular formula :

C14H22O2.

Effective Concentration :

1-10 μM.

Activity :

tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.

Reconstitution and Solubility :

Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to one week at 4°C.Protect from light.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

88-58-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Chemical Name :

2,5-Ditert-butylbenzene-1,4-diol.

more info or order :

Alomone Labs product webpage