chemical

TCN 213

T-215

T-215_10 mg

TCN 213

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

TCN 213 acts as a selective and potent NMDA (methyl-d-aspartate) receptor antagonist. This compound displays a high selectivity for GluN1/GluN2A-containing NMDAR receptors over GluN1GluN1/GluN2B containing NMDAR receptors. The degree of its antagonism is dependent on the concentration of the GluN1-site co-agonist, glycine or d-serine, and is independent of the glutamate concentration1. Relatively high concentrations of TCN 213 are required to achieve substantial block of GluN2A NMDAR-mediated responses.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.

Alomone Labs

NMDA receptors

TCN 213 (#T-215) is a highly pure, synthetic, and biologically active compound.

An Antagonist of NMDA Receptors

376.54

AC1M9FKI

Synthetic

C18H24N4OS2.

1 µM - 1 mM.

TCN 213 is a NMDA receptor antagonist, selective for NR2A- over NR2B-containing receptors. Inhibits human recombinant NR1/NR2A with pIC50 of 5.4 in FLIPR/Ca2+ assay1.

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

556803-08-8

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclohexylmethyl)acetamide.