(RS)-(Tetrazol-5-yl)glycine | Alomone Labs T-205 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

(RS)-(Tetrazol-5-yl)glycine

catalog :

T-205

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Phenytoin inhibits NaV1.2 channel currents in Xenopus oocytes. - A. Time course of current reversible inhibition by 50 and 250 M Phenytoin (#P-235) as measured at peak current amplitude. Currents were elicited by a voltage step protocol from a holding potential of -60 mV to -10 mV delivered every 10 seconds. B. Example traces of current responses before and during 50 and 250 M Phenytoin application.

product information

CAT :

T-205

SKU :

T-205_10 mg

Product Name :

(RS)-(Tetrazol-5-yl)glycine

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

(RS)-(Tetrazol-5-yl)glycine is a synthetic compound that acts as highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. The compound is significantly more potent than NMDA or glutamate. When given to neonatal rats, (RS)-(Tetrazol-5-yl) glycine was found to be highly potent convulsant1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. They also mediate physiological functions such as learning and memory formation and participate in glutamate excitotoxicity2.(RS)-(Tetrazol-5-yl)glycine inhibits [3H]glutamate binding to rat brain NMDA receptors with an IC50 value of 36 nM1. in vitro studies show that (RS)-(Tetrazol-5-yl)glycine can activate NR1/NR2A NMDA receptors with an EC50 value of 1.77 µM3.

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

(RS)-(Tetrazol-5-yl)glycine (#T-205) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent NMDA Receptor Agonist

MW :

143.1

Synonyms :

Tet-glycine, Tetrazolylglycine, Tetrazol-5-yl-gly, 5-Tetrazolyl-glycine, LY 285 265

Source :

Synthetic

Molecular formula :

C3H5N5O2.

Effective Concentration :

0.1-25 µM.

Activity :

(RS)-(Tetrazol-5-yl)glycine is a highly potent and selective NMDA receptor agonist (significantly more potent than NMDA or glutamate), inhibiting [3H]glutamate binding to rat brain NMDA receptors with IC50 of 36 nM1. in vitro, it activates NR1/NR2A NMDA receptors with EC50 of 1.77 µM2.

Reconstitution and Solubility :

Soluble up to 25 mM in water, with gentle heating. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Soluble up to 25 mM in water, with gentle heating. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to prepare fresh solutions before use, or aliquot stock solutions stored at -20°C. Prevent repeated thawing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

138199-51-6

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-amino-2-(2H-tetrazol-5-yl)acetic acid.

more info or order :

Alomone Labs product webpage