TC-I 2014 | Alomone Labs T-200 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

TC-I 2014

catalog :

T-200

more info or order :

Alomone Labs product webpage

product information

CAT :

T-200

SKU :

T-200_10 mg

Product Name :

TC-I 2014

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

TC-I 2014 is a selective TRPM8 channel blocker. The compound shows high affinity towards TRPM8 and exhibits in vitro functional activity and good oral efficacy in an inflammatory model of neuropathic pain1. TC-I 2014 inhibits canine, rat, and human TRPM8 mediated Ca2+ influx functional assays with IC50 values of 0.8, 4.0, and 3.0 nM, respectively1.TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is a Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons. Its expression is up-regulated in prostate cancer and other malignancies1,2.

Supplier :

Alomone Labs

Target :

TRPM8 channel

Long Description :

TC-l-2014 (#T-200) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Blocker of TRPM8 Channels

MW :

467.41

Source :

Synthetic

Molecular formula :

C23H19F6N3O.

Effective Concentration :

1 nM - 1 µM.

Activity :

TC-I 2014 is a potent and selective TRPM8 blocker, inhibiting canine, rat, and human TRPM8-mediated Ca2+ influx with IC50 values of 0.8, 4.0, and 3.0 nM, respectively1.

Reconstitution and Solubility :

Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96%

CAS No :

1221349-53-6

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene.

more info or order :

Alomone Labs product webpage