TCN 201 | Alomone Labs T-190 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

TCN 201

catalog :

T-190

more info or order :

Alomone Labs product webpage

citations: 2

Reference
Chan K, Nestor J, Huerta T, Certain N, Moody G, Kowal C, et al. Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory. Nat Commun. 2020;11:1403 pubmed publisher
Hildebrand M, Pitcher G, Harding E, Li H, Beggs S, Salter M. GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord. Sci Rep. 2014;4:4094 pubmed publisher

image

image 1 :

Alomone LabsVU591blocks Kir1.1 channels expressed inXenopusoocytes. - A. Kir1.1 channel currents were elicited by 150 ms voltage ramp from -120 mV to +60 mV (HP -90 mV no leak subtraction).VU591(#V-125) was applied at 5 and 25 M as indicated and inhibited the Kir1.1 channel current in a dose dependent and reversible manner. B. Example current traces before and during application of 5 and 25 M VU591 from the experiment shown in A.

product information

CAT :

T-190

SKU :

T-190_10 mg

Product Name :

TCN 201

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

TCN 201, a sulphonamide derivative, acts as a selective and potent NMDA (methyl-D-aspartate) receptor antagonist. This compound displays a high selectivity for GluN1/GluN2A-containing NMDAR receptors over GluN1/GluN2B containing receptors and acts in a non-competitive manner. The degree of its antagonism is dependent on the concentration of the GluN1-site co-agonist, glycine or D-serine, and is independent of the glutamate concentration1. TCN 201 can be used to estimate and to clarify the contribution of NMDAR subunit and its composition and function.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

TCN 201 (#T-190) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of NMDA Receptors

MW :

461.89

Synonyms :

QCR-22

Source :

Synthetic

Molecular formula :

C21H17ClFN3O4S.

Effective Concentration :

0.1-10 µM.

Activity :

TCN 201 blocks NR1/NR2A NMDA receptors in an NR1 co-agonist dependent and non-competitive manner1, selective for NR2A- over NR2B-containing receptors, with pIC50 of 6.8 on human recombinant NR1/NR2A in FLIPR/Ca2+ assay2.

Reconstitution and Solubility :

Up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

852918-02-6

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide.

more info or order :

Alomone Labs product webpage