Tanshinone II-A sodium sulfonate | Alomone Labs T-165 product information

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product summary

company name :

Alomone Labs

product type :

chemical

product name :

Tanshinone II-A sodium sulfonate

catalog :

T-165

product information

CAT :

T-165

SKU :

T-165_10 mg

Product Name :

Tanshinone II-A sodium sulfonate

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

KCa1.1 channel is a large conductance Calcium-activated potassium channel (BKCa) known to regulate the repolarization of action potential discharge through molecular association with high voltage activated calcium channels.Tanshinone II-A sodium sulfonate (TIIAS) is a water soluble derivative of Tanshinone IIA. Tanshinone IIA is an active constituent of the herb Danshen (Salvia miltiorrhiza) widely used in Chinese traditional medicine for coronary artery disease, hypertension and other cardiovascular diseases due to its properties of arterial dilatation. TIIAS is a synthetic opener of KCa1.1 channels with an effective concentration 10-200 μM. TIIAS increases the total permeability of BKCa in a concentration dependent manner. TIIAS has an EC50 of 111.5 μM at 0.01 μM Ca2+ and an EC50 of 68.5 μM at 0.1 μM Ca2+ 2. Similar to Danshen, TIIAS has beneficial effects on cardiac vasodilatation, reduction of oxidative stress and lipid profile. Interestingly, when used in a rat model of preeclampsia TIIAS reduced oxidative stress, however it did not lead to an improvement in pregnancy outcome criteria such as maternal blood pressure and fetal biometrics3. TIIAS was also found to have analgesic properties in neuropathic pain via inhibition of the spinal astrocytic JNK/MCP-1 pathway and the reduction of IL-1β and TNF-α expression4.

Supplier :

Alomone Labs

Target :

KCa1.1 channel

Long Description :

Tanshinone II-A sodium sulfonate (#T-165) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Opener of KCa1.1 Channel

MW :

396.4

Synonyms :

DS-201

Source :

Synthetic

Molecular formula :

C19H17O6SNa.

Effective Concentration :

10-200 µM.

Activity :

Tanshinone II-A sodium sulfonate is a KCa1.1 channel opener1.

Reconstitution and Solubility :

10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

≥98%

CAS No :

69659-80-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate.