Trimethylapigenin | Alomone Labs T-145 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Trimethylapigenin

catalog :

T-145

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs Trimethylapigenin inhibits KV1.5 channels expressed in Xenopus oocytes. - A. Time course of KV1.5 plateau current amplitude elicited by 150 ms voltage step from holding potential of -80 mV to +50 mV delivered every 10 seconds. Application of 150 MTrimethylapigenin(#T-145) inhibits KV1.5 currents in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 150 M Trimethylapigenin as indicated.

image 2 :

Expression of VGLUT1 in rat cortex - Immunohistochemical staining of perfusion-fixed rat brain frozen sections using Anti-VGLUT1 Antibody(#AGC-035) (1:400) followed by goat-anti-rabbit-Alexa-488. VGLUT1 staining (green) appears in neurons of the pyramidal layer of the parietal cortex (arrows). DAPI is used as the nuclear counterstain (blue).

product information

CAT :

T-145

SKU :

T-145_10 mg

Product Name :

Trimethylapigenin

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Trimethylapigenin is a natural flavone and a fully methylated derivate of apigenin, present in citrus, kaempferia parviflora, etc. Trimethylapigenin inhibits cardiac potassium currents. This compound blocks KV1.5 current in HEK 293 cell line (IC50 = 6.4 μM), and the ultra-rapid delayed rectify K+ current (IKur) in human atrial myocytes (IC50 = 8.0 μM) by binding to the open channels. In addition, trimethylapigenin decreased transient outward K+ current (Ito) in human atrial myocytes, inhibited acetylcholine-activated K+ current (IC50 = 6.8 μM) in rat atrial myocytes1.It has been demonstrated that trimethylapigenin is effective in modulating bacterial drug resistance, and in α-glycosidase inhibition, anti-adipogenesis, anti-carcinoma, anti-inflammation, and chemoprevention. In addition, trimethylapigenin has been found to activate CFTR Cl− channels1.

Supplier :

Alomone Labs

Target :

KV1.5, KV11.1, CFTR channels

Long Description :

Trimethylapigenin (#T-145) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of KV1.5 and KV11.1 and an Activator of CFTR Channels

MW :

312.3

Source :

Synthetic

Molecular formula :

C18H16O5.

Effective Concentration :

1-200 µM.

Activity :

Trimethylapigenin blocks KV1.5 and hERG channels with IC50 ~ 8 and 30 μM respectively. It also activates CFTR channels1.

Reconstitution and Solubility :

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Solubility :

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96%

CAS No :

5631-70-9

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one.

more info or order :

Alomone Labs product webpage