product summary
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company name :
Alomone Labs
product type :
chemical
product name :
TTA-A2
catalog :
T-140
more info or order :
citations: 14
| Reference |
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Sankhe S, Manousakidi S, Antigny F, Arthur Ataam J, Bentebbal S, Ruchon Y, et al. T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension. Biochim Biophys Acta Mol Cell Res. 2017;1864:1631-1641 pubmed publisher
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image
image 1 :
Alomone Labs TTA-A2 blocks T-type CaV channels expressed in Xenopus oocytes. - A. Time course of CaV3.2 peak current amplitude elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV delivered every 10 seconds. Application of 100 MTTA-A2(#T-140) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar).B. Representative current traces before and during application of 100 M TTA-A2as indicated.
product information
CAT :
T-140
SKU :
T-140_10 mg
Product Name :
TTA-A2
Group Type :
Non Antibodies
Product Type :
S. Molecules
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Product Page - Scientific background :
Low-voltage-activated (T-type/CaV3) Ca2+ channels are a subclass of voltage-dependent Ca2+ channels allowing Ca2+ entry near the resting potential of most cells1. Various synthetic T-channel blockers have been described in the past few years including TTA-A2, a potent, state-dependent, and highly selective T-type CaV antagonist2.TTA-A2 was found to inhibit all three subtypes of low-voltage-gated T-type channels (CaV3.1, CaV3.2, and CaV3.3) with comparable potencies. Changing membrane resting potentials from −100 to −80 mV enhanced compound potency ∼40-fold, from an IC50 of ∼4 μM to 0.1 μM, respectively, indicating state dependence of inhibition3. in vivo studies have demonstrated that TTA-A2 reduces absence epilepsy seizures4, pain perception5, nicotine self-administration6 and weight gain7. It also improves the quality of sleep7 and displays antipsychotic properties8.
Supplier :
Alomone Labs
Target :
T-type CaV channels
Long Description :
TTA-A2 (#T-140) is a highly pure, synthetic, and biologically active compound.
Short Description :
A Blocker of T-Type CaV Channels
MW :
378.39
Source :
Synthetic
Molecular formula :
C20H21F3N2O2.
Effective Concentration :
0.05-100 µM.
Activity :
TTA-A2 blocks T-type CaV channels with an IC50 of ~100 nM (at -100 mV holding potential) and ~5 µM (at holding potential -80 mV).
Reconstitution and Solubility :
100mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Solubility :
100mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage of solutions :
Up to four weeks at 4°C or three months at -20°C.
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Purity :
>99%
CAS No :
953778-63-7
Form :
Lyophilized powder.
Comment :
Contact Alomone Labs for technical support and product customization
UNSPSC :
41116134
Bioassay Tested :
Yes
Cited Application :
Electrophysiology
Chemical Name :
(R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl) acetamide.
more info or order :
company information
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com972 2 531 8002
headquarters: Israel
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