chemical

Tropanyl-3,5-dimethylbenzoate

T-135

T-135_100 mg

Tropanyl-3,5-dimethylbenzoate

Non Antibodies

S. Molecules

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropanyl-3,5-dimethylbenzoate is a synthetic, potent and selective antagonist of the 5-HT3 receptor. Tropanyl-3,5-dimethylbenzoate has an effective concentration of 1 nM - 1 μM. Interestingly, in rat mucosa and submucosa preparations Tropanyl causes an increase of 5-HT induced Δ/sc (change in short circuit current) and causes a decline of Δ/sc in rat intact colon suggesting a double role for 5-HT3 receptors in this tissue2.

Alomone Labs

5-HT3 receptors

Tropanyl-3,5-dimethylbenzoate (#T-135) is a highly pure, synthetic, and biologically active compound.

An Antagonist of 5-HT3 Receptors

273.4

Synthetic

C17H23NO2.

1 nM - 1 µM.

Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist1.

50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

85181-40-4

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate.