chemical

Tropisetron hydrochloride

T-125

T-125_10 mg

Tropisetron hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropisetron hydrochloride is a synthetic, potent and selective antagonist of 5-HT3A channel. In fluorescence polarization it was found to have an affinity 8.31 pKi (M) for 5-HT3A receptor2. Tropisetron binds to an extracellular domain of the receptor. Tropisetron was found to have an analgesic and anti-inflammatory activity via inhibition of lipopolysaccharide (LPS) stimulated tumor necrosis factor (TNF) and interleukin-1-β release from human monocytes. This inhibition is conducted by preventing the phosphorylation of the p38 mitogen activated kinase (MAPK)3. Interestingly, when combined with acetaminophen in an experimental pain inducing assay, Tropisetron blocked the analgesic effect of acetaminophen thus indicating that perhaps the analgesic action of acetaminophen is also mediated through 5-HT receptors4.

Alomone Labs

5-Hydroxytryptamine Receptor 3A

Tropisetron hydrochloride (#T-125) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of 5-Hydroxytryptamine Receptor 3A

320.76

Synthetic

C17H21ClN2O2.

0.1-10 nM.

Tropisetron hydrochloride is a potent and selective 5-HT3A channel blocker with Ki ~ 2 nM1.

50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

105826-92-4

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride.