Myrmicitoxin1-Pm2a | Alomone Labs STP-040 product information

product summary

company name :

Alomone Labs

product type :

protein

product name :

Myrmicitoxin1-Pm2a

catalog :

STP-040

more info or order :

Alomone Labs product webpage

product information

cat :

STP-040

SKU :

STP-040_1 mg

Product Name :

Myrmicitoxin1-Pm2a

Group Type :

Non Antibodies

Product Type :

Proteins

Accession :

P0DRD1

Accession Number :

https://www.uniprot.org/uniprotkb/P0DRD1/entry

Applications :

Electrophysiology

Formulation :

Lyophilized Powder.

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Reconstitution and Solubility :

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. Avoid multiple freeze-thaw cycles to maintain biological activity. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%–0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended.

Storage Before Reconstitution :

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Origin :

Pogonomyrmex maricopa (Maricopa harvester ant)

Source :

Synthetic peptide

Gene ID :

SCN8A, SCN9A, SCN10A, SCN11A

Product Page - Scientific background :

Myrmicitoxin1-Pm2a (Pm2a) is a 27-amino acid peptidyl toxin originally isolated from the venom of the harvester ant, Pogonomyrmex maricopa. Pm2a toxin is a potent modulator of mammalian voltage-gated sodium (NaV) channels, reducing the voltage threshold for activation and inhibiting channel inactivation. This toxin has been shown to be particularly potent in modulating NaV1.7 (EC50=154 ± 17 nM), NaV1.6 (EC50 = 176 ± 56 nM), NaV1.8 (EC50=2600 ± 700 nM), and NaV1.9 (EC50=

Supplier :

Alomone Labs

Target :

Nav1.7, Nav1.6, Nav1.8 and Nav1.9 channels

Long Description :

Myrmicitoxin1-Pm2a (#STP-040) is a highly pure, synthetic, and biologically active peptide toxin.

MW :

3189.9 Da

Synonyms :

Myrmicitoxin1-(MYRTX1)-Pm2a, MYRTX1-Pm2a, Pm2a

Modifications :

Asn27 – C-terminal amidation

Molecular formula :

C157H238N36O33S1

Effective Concentration :

100 nM - 3 µM

Activity :

Pm2a toxin potently modulates mammalian voltage gated sodium (NaV) channels, reducing the voltage threshold for activation and inhibiting channel inactivation1. Pm2a modulates NaV1.6 and NaV1.7, as well as TTX-resistant channels such as NaV1.8 and NaV1.9¹.

Storage of solutions :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Purity :

≥98% (HPLC)

Form :

Lyophilized

Comment :

Contact Alomone Labs for technical support and product customization

Sequence :

ALPALPLLMFLFTLPALQHWIEKNWIN – NH2

Is Toxin :

Yes

UNSPSC :

12352202

Bioassay Tested :

yes

Steril endotoxin free :

more info or order :

Alomone Labs product webpage