chemical

ω-Conotoxin FVIA

STC-780

STC-780_0.1 mg

ω-Conotoxin FVIA

Non Antibodies

Proteins

P0DW83

https://www.uniprot.org/uniprotkb/P0DW83/entry

Electrophysiology

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus fulmen (Thunderbolt cone) (Chelyconus fulmen)

Synthetic peptide

CACNA1B

ω-Conotoxins are disulfide-rich peptides comprised of 24-31 amino acids, isolated from the venom of marine predatory cone snails. They have a high content of basic amino acid residue and common cysteine scaffold that stabilizes the four-loop framework1,2.ω-Conotoxin FVIA is originally isolated from Conus Fulmen. It is a selective, potent and reversible voltage-gated N-Type Ca2+ (CaV2.2) channel blocker that preferentially blocks nociception in inflammatory pain models, and allodynia and hyperalgesia in neuropathic pain models1,2. Studies have shown that ω-Conotoxin FVIA demonstrates analgesic potency and greater reversibility for the treatment of refractory pain and low side effects1.Voltage-gated N-Type Ca2+ channels are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signals. They are able to transduce electrical activity into other cellular functions and regulate calcium homeostasis2.

Alomone Labs

CaV2.2 channels

A Potent Blocker of CaV2.2 Channel

A Potent Blocker of CaV2.2 Channel

2567 Da

Conotoxin FVIA

Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25 Cys25 - C-terminal amidation

C98H164N36O33S6

10 - 50 nM

ω-Conotoxin FVIA specifically and reversibly blocks N-type Ca2+ channels1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥99% (HPLC)

Lyophilized

Contact Alomone Labs for technical support and product customization

CKGTGKSCSRIAYNCCTGSCRSGKC-NH2

Yes

12352202

yes

no