chemical

ω-Conotoxin MVIID

STC-751

STC-751_0.1 mg

ω-Conotoxin MVIID

Non Antibodies

Proteins

Q26350

https://www.uniprot.org/uniprotkb/Q26350/entry

Electrophysiology

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus magus (Magical cone)

Synthetic peptide

CACNA1A,CACNA1B

ω-conotoxins are small, disulfide-rich peptides from the venoms of predatory cone snails that inhibit neuronal voltage-gated Ca2+ channels involved in neurotransmitter release. ω-conotoxin-MVIID (ω-CTx-MVIID) was identified by sequence homology from Conus magus (Magician's cone snail) cDNA library1,4. ω-CTx-MVIID blocks Ca2+ current activated in whole-cell patch-clamp recordings from central neurons of goldfish2. ω-conotoxin MVIID exhibits greater discrimination against the N-channel subtype than any other ω-conotoxin variant to date. ω-conotoxin MVIID has effects on "P-like" subtypes of Ca2+ channels. Furthermore, ω-CTx-MVIID inhibits synaptosomal voltage-sensitive Ca2+ uptake3.

Alomone Labs

N-, P-type Ca2+ channels

A Blocker of N- and P-Type CaV Channels

A Blocker of N- and P-Type CaV Channels

2695 Da

SNX-238

Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25 Cys25 - C-terminal amidation

C99H164N42O33S7

200 nM - 1 µM

ω-Conotoxin MVIID is a voltage-gated N-type Ca2+ channel blocker1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

153887-08-2

Lyophilized

Contact Alomone Labs for technical support and product customization

CQGRGASCRKTMYNCCSGSCNRGRC-NH2

Yes

12352202

yes

no