chemical

Conantokin G

STC-666

STC-666_0.5 mg

Conantokin G

Non Antibodies

Proteins

P07231

https://www.uniprot.org/uniprotkb/P07231/entry

Electrophysiology

Lyophilized from double distilled water (ddH2O).

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus geographus (Geography cone) (Nubecula geographus)

Synthetic peptide

GRIN2B

Conantokin G is a 17 amino acid peptide toxin originally isolated from Conus geographus venoM The toxin acts as a selective antagonist of the GluN2B, a subunit of NMDA receptors1-3. Conantokin G structure includes γ-carboxiglutamic acid which coordinates binding of 4 calcium ions1,2.Conantokin G has IC50 values of 0.48 µM in hippocampal and cortical neurons, and 0.1 µM in Xenopus oocytes expressing the GluN1-GluN2B subunits1. In vitro studies of neuronal cultures have revealed anti-apoptotic properties of Conantokin G. In animal models, Conantokin G has been successfully tested as an anti-convulsant and as an anti-analgesic agent.NMDA receptors belong to the family of ionotropic receptors coactivated by glutamate and glycine. They play a central role in neuronal plasticity, learning, and memory3.

Alomone Labs

GluN2B receptor

A Selective and Competitive Antagonist of GluN2B Receptor

A Selective and Competitive Antagonist of GluN2B Receptor

2264.2 Da

Con-G, CGX-1007, Conotoxin GV, Sleeper peptide

X = 4-Carboxyglutamate, Asp17 - C-terminal amidation

C88H138N26O44

500 nM

ConantokinG is a GluN2B competitive antagonist1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

93438-65-4

Lyophilized

Contact Alomone Labs for technical support and product customization

GEXXLQXNQXLIRXKSN-NH2

Yes

12352202

yes

no