chemical

ω-Conotoxin CVIC

STC-420

STC-420_0.1 mg

ω-Conotoxin CVIC

Non Antibodies

Proteins

P58919

https://www.uniprot.org/uniprotkb/P58919/entry

Electrophysiology

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus catus (Cat cone)

Synthetic peptide

CACNA1A,CACNA1B

ω-Conotoxin CVIC is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage-gated N-,P- and Q-type CaV channels. CVIC has an effective concentration of 10-50 nM with an IC50 of 7.6 nM for N-type channels and 31 nM for P- and Q-type channels. Compared to other ω-conotoxins, CVIC is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIC's mRNA transcript thus suggesting that this ω-conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family1.

Alomone Labs

N-, P/Q-type channels

A Blocker of N-, P/Q-Type Ca2+ Channels

A Blocker of N-, P/Q-Type Ca2+ Channels

2783 Da

Omega-conotoxin CVIC

Disulfide bonds between: Cys1-Cys16, Cys8-Cys20, and Cys15-Cys26 Cys26 - C-terminal amidation

C107H180N38O35S7

10 - 50 nM

ω-Conotoxin CVIC is a blocker of N-, P/Q-type CaV channels1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

Lyophilized

Contact Alomone Labs for technical support and product customization

CKGKGQSCSKLMYDCCTGSCSRRGKCS-NH2

Yes

12352202

yes

no