chemical

ω-Conotoxin MoVIA

STC-150

STC-150_0.1 mg

ω-Conotoxin MoVIA

Non Antibodies

Proteins

A0A384E129

https://www.uniprot.org/uniprotkb/A0A384E129 /entry

Electrophysiology

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus moncuri (Sea snail)

Synthetic peptide

CACNA1B

ω-Conotoxin MoVIA (MoVIA) is a 29 amino acid peptidyl toxin originally isolated from the venom of the western Pacific vermivorous (worm-hunting) cone snail, Conus moncuri. MoVIA is a specific and potent blocker of mammalian N-type voltage-gated Ca2+ channels (CaV2.2)1.MoVIA has an arginine at position 13 instead of a tyrosine, which has been previously shown to be functionally critical for the potent Cav2.2 inhibitor activity of ω-conotoxins including ω-Conotoxin MVIIA (#C-670) and ω-Conotoxin GVIA (#C-300) from piscivorous (fish-hunting) species1.CaV2.2 are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signaling. These channels are multifunctional and play important roles in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions, regulate calcium homeostasis and process pain information. Since ω-conotoxins selectively inhibit Cav2.2 in nociceptors, they are considered attractive molecules for drug design2.

Alomone Labs

Cav2.2

A Potent Blocker of CaV2.2 Channel

A Potent Blocker of CaV2.2 Channel

3607 Da

Omega-conotoxin MoVIA

Disulfide bonds between: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26 X = Hydroxyproline

C147H233N45O47S7

100 nM - 2 µM

A selective Cav2.2 blocker1

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

Lyophilized

Contact Alomone Labs for technical support and product customization

CKPXGSKCSXSMRDCCTTCISYTKRCRKYYN-OH

Yes

12352202

yes

no