chemical

α-Conotoxin TxID

STC-110

STC-110_0.1 mg

α-Conotoxin TxID

Non Antibodies

Proteins

K8DWB5

https://www.uniprot.org/uniprotkb/K8DWB5 /entry

Electrophysiology

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Conus textile (Cloth-of-gold cone)

Synthetic peptide

CHRNA3,CHRNA6,CHRNA2, CHRNB4

α-Conotoxin TxID (a-CTx TxID) is a 15 amino acid peptidyl toxin isolated from the mollusk-hunting cone snail, Conus textile. This toxin belongs to the α-4/6 conotoxin (α-CTx) subfamily, that potently blocks the α3β4 nicotinic acetylcholine receptor (nAChR) subtype with high selectivity. In addition, α-CTx TxID blocks the closely related α6/α3β4 nAChR but exhibits minimal activity towards other nAChR subtypes. α-CTx TxID is the most potent α3β4 nAChR antagonist characterized thus far and has a unique selectivity profile 1.Neuronal nAChRs are widely distributed throughout the central and peripheral nervous systems. These receptors play important roles in normal physiology and are involved in many diseases such as epilepsy, pain, addiction, Alzheimer's disease, Parkinson's disease, schizophrenia, as well as breast and lung carcinoma. The α3β4 nAChR is the most prevalent subtype in the brain and is associated with nicotine addiction, neuropathic pain and small cell lung cancer2. Given the diverse functions of the nAChRs, the a-CTx TxID may be a valuable tool for elucidating the distinct roles of the α3β4 nAChRs in a variety of normal and pathological processes1,3. a-CTx TxID has been used for these purposes and it was recently shown to exhibit anti-tumor activity, which may provide novel strategies for cancer treatment4.

Alomone Labs

α3/β4 nAChR

A Potent Antagonist of α3/β4 Neuronal nAChR.

A Potent Antagonist of α3/β4 Neuronal nAChR.

1489.8 Da

Alpha-conotoxin TxID, α-CTx TxID

Disulfide bonds between: Cys2-Cys8, Cys3-Cys15Cys15 - C-terminal amidation

C58H92N18O18S5

20 - 500 nM

α-Conotoxin TxID is a potent α3/β4 nAChR antagonist and α6/α3β4 blocker1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

1496617-64-1

Lyophilized

Contact Alomone Labs for technical support and product customization

GCCSHPVCSAMSPIC-NH2

Yes

12352202

yes

no