chemical

human, rat Spexin-1

SPS-100

SPS-100_1 mg

human, rat Spexin-1

Non Antibodies

Proteins

Q9BT56

https://www.uniprot.org/uniprotkb/Q9BT56/entry

Aequorin functional assay / Calcium imaging assay

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

GALR2, GALR3

Spexin-1 is a potent 14 amino acid neuropeptide that acts as a Galanin 2 (GALR2) and Galanin 3 (GALR3) receptor agonist, and shows no activity towards Galanin receptor 1.Expression of spexin-1 at the mRNA and protein levels are detected in the brain and in peripheral tissues of humans, mice and rats. Studies have shown that and administration of Spexin-1 leads to weight loss in rodents and suppresses appetite in goldfish1.GalR2 and GalR3 receptors are implicated in several biological functions, in which the central nervous system functions controlling memory, seizure, pain, anxiety, depression, and mood disorder2.

Alomone Labs

Galanin 2, Galanin 3 receptors

A Potent Agonist of Galanin 2 and Galanin 3 Receptors

A Potent Agonist of Galanin 2 and Galanin 3 Receptors

1620 Da

NPQ, Neuropeptide Q, Spexin hormone, NPQ 53-70

Gln14 - C-terminal amidation

C74H114N20O19S

20 - 50 nM

Spexin-1 is a Galanin 2 and Galanin 3 receptor agonist1.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

1370290-58-6

Lyophilized

Contact Alomone Labs for technical support and product customization

NWTPQAMLYLKGAQ-NH2

No

12352202

yes

no