chemical

[Y]6-Angiotensin II Analog

SPA-175

SPA-175_0.1 mg

[Y]6-Angiotensin II Analog

Non Antibodies

Proteins

Western blot

Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Centrifuge the vial (10,000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.

Synthetic peptide

AGTR2

Y6-Angiotensin II Analog is a potent and selective agonist of Angiotensin II type 2 receptor (AT2R)1. Studies show that it can be used as a safe and effective therapeutic tool for pancreatic ductal adenocarcinoma1.Local administration of Y6-Angiotensin II Analog causes AT2R gene expression in tumor cells and significantly attenuates the growth of fast growing murine pancreatic ductal adenocarcinoma tumors. This evidence may suggest that AT2R agonist therapy is an effective and useful procedure for pancreatic ductal adenocarcinoma treatment2.Y6-Angiotensin II Analog shows two distinct sets of proton resonances in aqueous solution, cis and trans conformations1. The cis isomer contains aromatic rings of Tyr6 and Phe8 stacked around the Pro7 ring, thus leading to a compact hydrophobic motif1.Angiotensin II type 2 receptor belongs to the superfamily of G-protein coupled receptors. The receptor mediates angiotensin II actions involved in vasodilation and anti-proliferation2.

Alomone Labs

AT2 receptor

A Potent and Selective AT2R Agonist

A Potent and Selective AT2R Agonist

1072 Da

C53H73N11O13

1 - 100 nM

Y6-Angiotensin Analog is an AT2R agonist1,2.

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

1-2 Business Days

Israel/IL

≥98% (HPLC)

Lyophilized

Contact Alomone Labs for technical support and product customization

DRVYIYPF-OH

No

12352202

yes

no